- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Transcription Factor ETS1 Antibody / Protein C-ets-1 [clone r1G11] (V5883)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5883-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5883-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5883SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | r1G11 |
| UniProt | P14921 |
| Localization | Cytoplasm, Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This Transcription Factor ETS1 antibody is available for research use only. |
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Transcription Factor ETS1 antibody recognizes ETS1, a member of the ETS family of transcription factors that regulate gene expression programs involved in cell differentiation, proliferation, survival, and immune function. ETS1 is encoded by the ETS1 gene and is also historically referred to as Protein C-ets-1, reflecting its identification as the cellular homolog of the avian v-ets oncogene. ETS1 functions primarily as a nuclear protein, where it binds specific DNA sequences containing ETS motifs to modulate transcriptional activity in response to developmental and signaling cues.
ETS1 plays a well-established role in lymphoid biology, where it contributes to the regulation of T cell, B cell, and natural killer cell development. It influences cytokine gene expression, T cell receptor signaling responses, and immune cell activation thresholds. Beyond the immune system, ETS1 is involved in endothelial biology, vascular remodeling, and angiogenic processes through transcriptional control of genes associated with extracellular matrix interaction and cell migration. Because of these functions, Transcription Factor ETS1 antibody is widely used to study transcriptional regulation in both immune and vascular contexts.
In cancer biology, ETS1 has been implicated in tumor progression, invasion, and metastasis in multiple solid tumor types. Altered ETS1 expression has been associated with changes in cell motility, matrix degradation, and epithelial-mesenchymal transition through regulation of proteases, adhesion molecules, and cytoskeletal regulators. ETS1 activity is often modulated by post-translational mechanisms, including phosphorylation, which fine-tune its transcriptional output in response to upstream signaling pathways. These features make ETS1 a relevant target for studies examining transcriptional networks in oncogenesis and tumor microenvironment interactions.
Transcription Factor ETS1 antibody, also referred to as Protein C-ets-1 antibody in the literature, supports detection of ETS1 expression and localization in research settings focused on transcriptional control mechanisms. Clone r1G11 is designed to recognize ETS1 and enables analysis of its nuclear distribution patterns consistent with its role as a DNA-binding transcription factor. Clone r1G11 is suitable for investigating ETS1 expression dynamics across different biological states, including immune activation, developmental processes, and disease-associated transcriptional remodeling.
By enabling specific detection of ETS1, this antibody provides a valuable tool for researchers examining ETS family transcription factors, gene regulatory networks, and signaling-dependent transcriptional responses. Its utility extends to studies of immune regulation, vascular biology, and cancer-related transcriptional programs where ETS1 plays a documented regulatory role.
1. Optimal dilution of the Transcription Factor ETS1 antibody should be determined by the researcher.
2. This Transcription Factor ETS1 antibody is recombinantly produced by expression in CHO cells.
Prokaryotic recombinant protein corresponding to amino acids 38 to 308 of the human Ets-1 oncoprotein isoform 2 was used as the immunogen for the Transcription Factor ETS1 antibody.
ETS1/Protein C-ets-1 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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