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Home >> Antibodies >> TRAF2 Antibody

TRAF2 Antibody (R32205)

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  Catalog No Formulation Size Price (USD)  
Image R32205 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 419
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Western blot testing of human 1) HeLa and 2) Jurkat lysate with TRAF2 antibody. Predicted/expected molecular weight ~56 kDa.
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Western blot testing of human 1) HeLa and 2) Jurkat lysate with TRAF2 antibody. Predicted/expected molecular weight ~56 kDa.
IHC testing of FFPE human tonsil with TRAF2 antibody. HIER: Boil the paraffin sections in pH 6, 10mM citrate buffer for 20 minutes and allow to cool prior to staining.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt Q12933
Localization Cytoplasmic
Applications Western blot : 0.1-0.5ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This TRAF2 antibody is available for research use only.
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Description

TRAF2 (TNF Receptor-Associated Factor 2), also called TRAP, is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. It is a common signal transducer for TNFR2 and CD40 that mediates activation of NF-kappa-B. Rothe et al. (1996) identified ITRAF, which binds to TRAF1, TRAF2, and TRAF3, and that when overexpressed inhibits TRAF2-mediated NF-kappa-B activation. They proposed that ITRAF is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Kanamori et al. (2002) found that mouse Traf2 interacted directly with T2bp, and they presented evidence that T2BP is involved in TNF-mediated signaling by its interaction with TRAF2.

Application Notes

Optimal dilution of the TRAF2 antibody should be determined by the researcher.

Immunogen

Amino acids RLDQDKIEALSSKVQQLERSIGLKDLAMADLE of human TRAF2 were used as the immunogen for the TRAF2 antibody.

Storage

After reconstitution, the TRAF2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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