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Home >> Antibodies >> TPX2 Antibody / p100

TPX2 Antibody / p100 [clone 19AT953.286.93] (F40193)

  Catalog No Formulation Size Price (USD)  
Image F40193-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F40193-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of lysate from HT29, Jurkat, MCF-7 cell line (left to right) using TPX2 antibody
Western analysis of extracts from Jurkat cells using TPX2 antibody.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 19AT953.286.93
Purity Purified
UniProt Q9ULW0
Applications Western blot : 1:100-1:1000
Limitations This TPX2 antibody is available for research use only.
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Description

TPX2/p100 is a spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. [UniProt]

Application Notes

Titration of the TPX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A KLH conjugated synthetic peptide from the human protein was used as immunogen for this TPX2 antibody.

Storage

Aliquot the TPX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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