- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TPPP3 Antibody / Tubulin polymerization-promoting protein family member 3 Antibody targets TPPP3, a member of the tubulin polymerization-promoting protein family. Microtubules are dynamic polymers that provide structural support, establish intracellular polarity, and form tracks for molecular motors. Proteins that interact with tubulin influence the balance between microtubule growth, stabilization, and disassembly. TPPP3 has been investigated as a microtubule-associated factor with potential roles in the organization of the cytoskeleton and the behavior of differentiating cells.
Members of the TPPP family share sequence features but are not functionally interchangeable. The founding family member TPPP/p25 has been studied extensively for effects on microtubule assembly and bundling, while TPPP3 remains less completely characterized. TPPP3 expression has been reported in tissues containing specialized epithelial and other differentiated cell populations. Its distribution has encouraged investigation of how cytoskeletal organization accompanies changes in cell shape and tissue architecture. Nevertheless, the presence of a TPPP-family domain does not by itself establish that every family member exerts the same biochemical effects on microtubules.
Microtubule organization is coordinated with actin filaments, intermediate filaments, and membrane trafficking machinery. Changes in this network can affect cell polarity, intracellular transport, and the positioning of organelles. TPPP3 has also appeared in studies of cellular differentiation and disease-associated expression changes, but the direct molecular steps connecting its abundance to particular phenotypes require further definition. Disentangling microtubule binding from indirect effects on cell state is central to interpreting these observations. NSJ Bioreagents offers this TPPP3 Antibody to help investigate the contribution of TPPP3 to cytoskeletal organization and differentiation-associated changes in cell architecture. More detailed characterization of its tubulin interactions may clarify where this family member overlaps with, or diverges from, other TPPP proteins.
Explore related research targets in our Cell Biology Antibodies collection.
The recommended approach is to establish the optimal working dilution of the TPPP3 Antibody / Tubulin polymerization-promoting protein family member 3 Antibody through preliminary testing.
The TPPP3 Antibody was generated using a synthetic peptide corresponding to a sequence at the N-terminus of human TPPP3.
After reconstitution, keep the TPPP3 Antibody at 4oC for up to one month. Alternatively, store aliquots at -20oC for up to six months. Avoid multiple freezing and thawing cycles.
TPPP3 antibody, Tubulin polymerization-promoting protein family member 3 antibody, tubulin polymerization promoting protein family member 3 antibody, TPPP/p20 antibody, p25gamma antibody, p20 antibody, CGI-38 antibody
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