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Home >> Antibodies >> TORC1 Antibody / CRTC1

TORC1 Antibody / CRTC1 (RQ5571)

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  Catalog No Formulation Size Price (USD)  
Image RQ5571 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of 1) rat brain, 2) mouse brain and 3) human HeLa lysate with TORC1 antibody. Predicted molecular weight ~67 kDa, routinely observed at 67-82 kDa.
Western blot testing of 1) rat brain, 2) mouse brain and 3) human HeLa lysate with TORC1 antibody. Predicted molecular weight ~67 kDa, routinely observed at 67-82 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt Q6UUV9
Applications Western blot : 0.25-0.5ug/ml
Limitations This TORC1 antibody is available for research use only.
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Description

CRTC1 (CREB-Regulated Transcription Coactivator 1), also known as MECT1, TORC1 or KIAA0616, is a protein that in humans is encoded by the CRTC1 gene. By sequence analysis, Tonon et al. (2003) mapped the CRTC1 gene to chromosome 19p13. Kovacs et al. (2007) found that Torc1 was expressed in adult mouse brain and cultured neurons, and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways. Mair et al. (2011) demonstrated that CRTC1 is a direct AMPK target, and interacts with the CREB homolog-1 (CRH1) transcription factor in vivo. The prolongevity effects of activating AMPK or deactivating calcineurin decrease CRTC1 and CRH1 activity and induce transcriptional responses similar to those of CRH1-null worms.

Application Notes

Optimal dilution of the TORC1 antibody should be determined by the researcher.

Immunogen

A human recombinant protein (amino acids E30-E568) was used as the immunogen for the TORC1 antibody.

Storage

After reconstitution, the TORC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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