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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TORC1 Antibody / CRTC1 (RQ5571)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5571 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q6UUV9 |
| Localization | Nuclear, cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells |
| Limitations | This TORC1 antibody is available for research use only. |
|
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TORC1 antibody is a valuable reagent for studying transcriptional regulation, neuronal plasticity, and metabolic control. The encoded protein, CRTC1 (CREB-regulated transcription coactivator 1), functions as a coactivator of CREB, the cAMP response element-binding protein. CRTC1 enhances CREB-dependent transcription by translocating to the nucleus in response to calcium and cAMP signaling. Once in the nucleus, it binds CREB at promoter regions, amplifying the expression of target genes involved in glucose metabolism, neuronal survival, and adaptive responses to stimuli.
CRTC1 is highly expressed in the brain, particularly in regions associated with learning and memory. Through its role as a CREB coactivator, TORC1 supports long-term potentiation and synaptic plasticity, processes essential for memory formation. Dysregulation of CRTC1 has been linked to neurodegenerative and psychiatric disorders, including Alzheimer disease, depression, and mood-related conditions, where impaired CREB-dependent transcription contributes to pathology.
Beyond the nervous system, CRTC1 influences metabolic pathways. It regulates gluconeogenic gene expression in the liver, thereby contributing to glucose homeostasis. By integrating signals from cAMP and calcium pathways, TORC1 coordinates cellular responses to nutritional and hormonal cues. Dysregulated CRTC1 activity has been implicated in metabolic disorders such as diabetes and obesity, making it an important target of interest in endocrinology and metabolism research.
At the molecular level, CRTC1 activity is tightly controlled by phosphorylation and cytoplasmic sequestration. Under resting conditions, TORC1 is phosphorylated and retained in the cytoplasm. Upon activation by signaling pathways, it becomes dephosphorylated and translocates into the nucleus, where it associates with CREB to enhance transcription. This regulatory cycle ensures precise control of CREB target gene expression in response to extracellular stimuli.
The TORC1 antibody is commonly used in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to measure expression levels, nuclear translocation, and disease-associated changes. These applications are valuable for research in neuroscience, metabolism, and signal transduction. For investigators exploring CREB signaling, neuronal adaptation, or metabolic regulation, the TORC1 antibody offers a dependable detection tool. NSJ Bioreagents provides validated antibodies designed to ensure reproducibility and accuracy in advanced molecular studies.
Optimal dilution of the TORC1 antibody should be determined by the researcher.
A human recombinant protein (amino acids E30-E568) was used as the immunogen for the TORC1 antibody.
After reconstitution, the TORC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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