- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Topo IIa Antibody / Topoisomerase II alpha [clone TOP2A/7148R] (V4496)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4496-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V4496-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4496SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | TOP2A/7148R |
| Purity | Protein A/G affinity |
| UniProt | P11388 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This Topo IIa antibody is available for research use only. |
|
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DNA Topoisomerase II alpha (TOP2A) is a nuclear enzyme that regulates DNA topology during DNA replication, transcription, and chromosome organization. Topo IIa Antibody / Topoisomerase II alpha (clone TOP2A/7148R) detects the TOP2A protein, a type II topoisomerase that resolves DNA supercoiling and DNA entanglements generated during genome duplication and chromatin remodeling. The enzyme introduces transient double strand DNA breaks that allow one DNA helix to pass through another, relieving torsional strain and maintaining proper chromosome architecture in proliferating cells.
Topo IIa Antibody / Topoisomerase II alpha (clone TOP2A/7148R) recognizes the TOP2A protein, a nuclear enzyme widely known as Topo IIa, a commonly used abbreviation for DNA Topoisomerase II alpha in the scientific literature. Topo IIa antibody, also referred to as Topoisomerase II alpha antibody or DNA Topoisomerase II alpha antibody, detects the enzyme responsible for controlling DNA topology and resolving structural DNA constraints generated during genome duplication and chromatin remodeling.
Topo IIa is a critical regulator of chromosome structure because it resolves DNA supercoiling, DNA knotting, and DNA catenation events that arise during DNA metabolic processes. By transiently cleaving and rejoining DNA strands, the enzyme allows intertwined DNA molecules to be separated and relieves torsional stress that accumulates during DNA replication and transcription. These activities help maintain proper chromosome organization and support efficient DNA metabolic activity within the nucleus.
The designation Topo IIa Antibody differentiates this antibody page from other Topoisomerase II alpha antibody pages by emphasizing the widely used Topo IIa abbreviation frequently referenced in molecular biology literature. Structuring antibody pages around alternative protein naming conventions such as Topo IIa is a useful strategy antibody vendors employ to ensure that multiple antibodies targeting the same protein are interpreted by search engines as distinct research reagents rather than duplicate content while still capturing common search terms used by researchers.
Topo IIa plays an essential role in maintaining chromosome structure and genomic integrity during cell division. Because the enzyme regulates DNA topology and resolves DNA entanglements generated during chromosome replication and condensation, antibodies recognizing Topo IIa support research investigating chromosome architecture, DNA topology control, and molecular mechanisms that regulate genome organization in proliferating cells.
Optimal dilution of the Topo IIa antibody should be determined by the researcher.
A synthetic peptide corresponding to human Topoisomerase II alpha protein (within amino acids 1431-1531) was used as the immunogen for the Topo IIa antibody.
Aliquot the Topo IIa antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
TOP2A antibody, DNA Topoisomerase II alpha antibody, Topoisomerase IIa antibody, Topo II alpha antibody, Topoisomerase II alpha antibody
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