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Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity). [UniProt]
The stated application concentrations are suggested starting points. Titration of the TOPK antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 58-86 from the mouse protein was used as the immunogen for the TOPK antibody.
Aliquot the TOPK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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