- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TOP2A Antibody / Topoisomerase II alpha [clone FB-20] (RQ5364)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
RQ5364 | Antibody in PBS with 0.02% sodium azide and 50% glycerol | 100 ul | 429 |
| Availability | 1-2 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | FB-20 |
| Purity | Affinity purified |
| UniProt | P11388 |
| Localization | Nuclear |
| Applications | Western blot : 1:500-1:2000 Immunohistochemistry (FFPE) : 1:50-1:200 |
| Limitations | This TOP2A antibody is available for research use only. |
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The TOP2A gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [RefSeq]
Optimal dilution of the TOP2A antibody should be determined by the researcher.
A synthetic peptide specific to human Topoisomerase II alpha / TOP2A was used as the immunogen for the TOP2A antibody.
Store the TOP2A antibody at -20oC.
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