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Home >> Antibodies >> Toll-like receptor 4 Antibody / TLR4

Toll-like receptor 4 Antibody / TLR4 (RQ7208)

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  Catalog No Formulation Size Price (USD)  
Image RQ7208 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Flow cytometry testing of human U937 cells with Toll-like receptor 4 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Toll-like receptor 4 antibody.
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Flow cytometry testing of human U937 cells with Toll-like receptor 4 antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Toll-like receptor 4 antibody.
Western blot testing of human HCCT cell lysate with Toll-like receptor 4 antibody. Predicted molecular weight ~96 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt O00206
Applications Western blot : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Direct ELISA : 0.1-0.5ug/ml
Limitations This Toll-like receptor 4 antibody is available for research use only.
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Description

TLR4, the human homolog of Drosophila Toll, is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat region and an intracellular domain homologous to that of human interleukin-1 receptor. The TLR4 gene is mapped to chromosome 9q32-q33 by fluorescence in situ hybridization. It detects lipopolysaccharide from Gram-negative bacteria and is thus important in the activation of the innate immune system. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns(PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

Application Notes

Optimal dilution of the Toll-like receptor 4 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids Q39-Q616) was used as the immunogen for the Toll-like receptor 4 antibody.

Storage

After reconstitution, the Toll-like receptor 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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