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Home >> Antibodies >> TNFSF15 Antibody / VEGI / TL1A

TNFSF15 Antibody / VEGI / TL1A [clone VEGI/7799R] (V5302)

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  Catalog No Formulation Size Price (USD)  
Image V5302-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5302-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5302SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human colon tissue with TNFSF15 antibody (clone VEGI /7799R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human colon tissue with TNFSF15 antibody (clone VEGI /7799R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free TNFSF15 antibody (clone VEGI /7799R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name VEGI/7799R
Purity Protein A affinity
UniProt O95150
Localization Secreted, Cell Surface, Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This TNFSF15 antibody is available for research use only.
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Description

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

Application Notes

Optimal dilution of the TNFSF15 antibody should be determined by the researcher.

Immunogen

Recombinant full-length human protein was used as the immunogen for the TNFSF15 antibody.

Storage

Aliquot the TNFSF15 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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