- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TNFRSF9 Antibody / 4-1BB / Tumor necrosis factor receptor superfamily member 9 / CD137 [clone rS16] (V5923)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5923-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5923-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5923SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgM, kappa |
| Clone Name | rS16 |
| UniProt | Q07011 |
| Localization | Cell membrane, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This TNFRSF9/4-1BB antibody is available for research use only. |
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TNFRSF9 antibody targets Tumor necrosis factor receptor superfamily member 9, a cell surface costimulatory receptor that is a member of the TNF receptor superfamily. TNFRSF9 is also widely known as 4-1BB and CD137 and is encoded by the TNFRSF9 gene. The protein is a type I transmembrane receptor primarily localized to the plasma membrane and is inducibly expressed following immune cell activation. TNFRSF9 antibody reagents are commonly used to study immune activation states due to the receptor's tightly regulated expression pattern.
TNFRSF9 expression is low or undetectable on resting T lymphocytes but is rapidly upregulated upon antigen stimulation. Activated CD8+ T cells show particularly strong induction of TNFRSF9, with additional expression observed on activated CD4+ T cells, natural killer cells, dendritic cells, and subsets of monocytes. Engagement of TNFRSF9 triggers intracellular signaling pathways that support cell survival, proliferation, and cytokine production, reinforcing immune responses during both acute and chronic stimulation.
As a costimulatory receptor, TNFRSF9 plays a central role in sustaining T cell effector function and promoting the formation of long-lived memory T cells. Antibody-based detection of TNFRSF9 is therefore widely applied in studies examining immune regulation, T cell differentiation, and immune exhaustion. Increased TNFRSF9 expression has been documented in inflammatory conditions and in tumor-infiltrating lymphocyte populations, making TNFRSF9 antibody tools valuable in immunology and cancer research contexts.
Beyond T cells, TNFRSF9 signaling influences interactions between immune cells within complex tissue environments. Expression of TNFRSF9 has been associated with immune activation in secondary lymphoid tissues and inflamed peripheral tissues. Analysis using a 4-1BB antibody enables researchers to assess costimulatory receptor dynamics and immune activation status across diverse experimental models. Clone rS16 is designed to recognize TNFRSF9 and is suitable for research applications focused on immune signaling, costimulatory receptor biology, and immune cell characterization.
1. Optimal dilution of the TNFRSF9//4-1BB antibody should be determined by the researcher.
2. This TNFRSF9//4-1BB antibody is recombinantly produced by expression in CHO cells.
Prokaryotic recombinant protein corresponding to a 140 amino acid sequence from the external domain of the N-terminus of the human CD137 molecule was used as the immunogen for the TNFRSF9/4-1BB antibody.
TNFRSF9//4-1BB antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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