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Home >> Antibodies >> TNFRSF1B Antibody / TNFR2

TNFRSF1B Antibody / TNFR2 (R32001)

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  Catalog No Formulation Size Price (USD)  
Image R32001 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 419
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Western blot testing of 1) human SW620, 2) human COLO-320, 3) human ThP-1, 4) human K562 and 5) mouse ANA-1 cell lysate with TNFRSF1B antibody. Predicted molecular weight: 50~80 kDa depending on glycosylation level.
Western blot testing of 1) human SW620, 2) human COLO-320, 3) human ThP-1, 4) human K562 and 5) mouse ANA-1 cell lysate with TNFRSF1B antibody. Predicted molecular weight: 50~80 kDa depending on glycosylation level.
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P20333
Localization Cytoplasmic, membrane
Applications Western blot : 0.5-1ug/ml
Limitations This TNFRSF1B antibody is available for research use only.
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Description

Tumor necrosis factor receptor 2 (TNFR2/TNFRSF1B) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

Application Notes

Optimal dilution of the TNFRSF1B antibody should be determined by the researcher.

Immunogen

Amino acids KKKPLCLQREAKVPHLPADKARGTQGPEQQH of human TNF Receptor II were used as the immunogen for the TNFRSF1B antibody.

Storage

After reconstitution, the TNFRSF1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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