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Home >> Antibodies >> TNFR2 Antibody

TNFR2 Antibody (R31080)

  Catalog No Formulation Size Price (USD)  
Image R31080 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
Western blot testing of TNFR2 antibody and Lane 1: rat spleen; 2: (r) brain; 3: mouse brain; 4: (m) HEPA cell lysate. Predicted molecular weight: 50/70~80kDa (unmodified/glycosylated).
Availability 1-3 business days
Species Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P25119
Localization Cytoplasmic, membrane
Applications Western blot : 0.5-1ug/ml
Limitations This TNFR2 antibody is available for research use only.
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Description

TNFRSF1B (Tumor Necrosis Factor Receptor Subfamily Member 1B), also known as TNFR2 or TNFBR, is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. By linkage analysis, Santee and Owen Schaub(1996) confirmed the mapping of the gene to 1p36.3-p36.2. TNFR2 is the larger of the two TNF receptors. It is present on many cell types, especially those of myeloid origin, and is strongly expressed on stimulated T and B lymphocytes. Beltinger et al.(1996) noted that TNFR2 is the main TNF receptor found on circulating T cells and is the major mediator of autoregulatory apoptosis in CD8+ cells. TNFR2 may act with TNFR1 to kill nonlymphoid cells.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the TNFR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of mouse TNF Receptor 2 (YECQISQEYYDRKAQMCC) was used as the immunogen for this TNFR2 antibody.

Storage

After reconstitution, the TNFR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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