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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PYCARD Antibody Biotin Conjugate (R35605BTN)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R35605BTN | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Biotin Conjugate |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 29108 |
| Applications | Western Blot : 1-3ug/ml ELISA (peptide) LOD : 1:32000 |
| Limitations | This PYCARD Antibody Biotin Conjugate is available for research use only. |
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PYCARD Antibody Biotin Conjugate recognizes PYCARD, also known as apoptosis-associated speck-like protein containing a CARD (ASC), a bipartite adaptor protein that serves as a central organizer of inflammasome signaling. PYCARD contains both a pyrin domain and a caspase recruitment domain, enabling it to bridge activated pattern recognition receptors with inflammatory caspases during innate immune responses. Through this adaptor function, PYCARD promotes assembly of multiprotein inflammasome complexes that activate caspase 1, stimulate inflammatory cytokine maturation, and initiate pyroptotic cell death. PYCARD Antibody Biotin Conjugate provides a convenient tool for sensitive detection of this key inflammasome adaptor using biotin-based immunodetection systems.
PYCARD functions downstream of several innate immune receptors, including NLRP3, AIM2, and additional inflammasome-forming sensors. Upon recognition of pathogens, danger-associated molecular patterns, or cellular stress, PYCARD rapidly oligomerizes into characteristic ASC specks that recruit inflammatory caspases and amplify innate immune signaling. These events lead to processing of interleukin 1 beta and interleukin 18 while promoting pyroptosis, an inflammatory form of programmed cell death that eliminates infected or damaged cells. As a result, PYCARD is widely studied in host defense, inflammation, and immune regulation.
Aberrant PYCARD activity has been implicated in infectious diseases, autoimmune disorders, chronic inflammatory conditions, neurodegenerative disease, cardiovascular pathology, metabolic disorders, and cancer. Because inflammasome activation plays a central role in both protective immunity and inflammatory pathology, PYCARD remains an important biomarker and potential therapeutic target. The biotin conjugate format is particularly useful for applications requiring enhanced detection sensitivity or flexible signal amplification through streptavidin-based detection systems.
NSJ Bioreagents' PYCARD Antibody Biotin Conjugate is suitable for immunohistochemistry, immunocytochemistry, immunofluorescence, flow cytometry, and other biotin-compatible immunoassays. By combining the specificity of a validated anti-PYCARD antibody with the versatility of biotin labeling, PYCARD Antibody Biotin Conjugate provides researchers with a reliable reagent for investigating inflammasome assembly, ASC speck formation, innate immune signaling, and inflammatory disease mechanisms across a broad range of experimental applications.
Learn more about PYCARD biology, inflammasome signaling, and additional validated products on our PYCARD Antibody page.
Optimal dilution of the PYCARD Antibody Biotin Conjugate should be determined by the researcher.
Amino acids RESQSYLVEDLERS were used as the immunogen for this TMS1 antibody.
Aliquot and store the PYCARD Antibody Biotin Conjugate at -20oC.
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