- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TMEM158 Antibody / Ras-Induced Senescence Protein 1 Antibody (F53826)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F53826-0.2ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.2 ml | 439 | |
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F53826-0.05ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.05 ml | 205 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Bovine |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | Q8WZ71 |
| RRID | AB_3753456 |
| Applications | Western Blot : 1:1000-2000 |
| Limitations | This TMEM158 Antibody / Ras-Induced Senescence Protein 1 Antibody is available for research use only. |
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TMEM158 Antibody / Ras-Induced Senescence Protein 1 Antibody recognizes TMEM158, also known as Ras-Induced Senescence Protein 1 (RIS1), a type I transmembrane protein originally identified as a gene induced during oncogenic Ras-driven cellular senescence. TMEM158 expression increases in response to sustained Ras signaling, linking it to the establishment and maintenance of senescence programs that limit uncontrolled cell proliferation. Although first characterized as a senescence-associated protein, subsequent studies have demonstrated that TMEM158 also participates in broader processes including cell growth, differentiation, adhesion, migration, and tumor progression, with its biological role varying according to tissue type and disease context.
TMEM158 is predominantly localized to cellular membranes and is expressed in numerous epithelial and mesenchymal tissues. Regulation of TMEM158 expression is influenced by mitogen-activated protein kinase signaling downstream of Ras, making it an informative marker for studies examining oncogene-induced stress responses. In normal physiology, TMEM158 has been implicated in cellular aging and the transition from proliferative to growth-arrested states. Experimental evidence also suggests interactions with pathways controlling extracellular matrix remodeling, cytoskeletal organization, and cell-cell communication, indicating that TMEM158 functions beyond a simple marker of senescence. These diverse activities have generated interest in the protein as a mediator of tissue remodeling and cellular adaptation to environmental stress.
The role of TMEM158 in cancer is complex and appears to be highly context dependent. In some tumor types, elevated expression is associated with oncogene-induced senescence, a tumor-suppressive mechanism that restricts malignant transformation. In contrast, other studies have reported increased TMEM158 expression in aggressive cancers, where it has been linked to enhanced cell migration, invasion, epithelial-to-mesenchymal transition, and metastatic potential. These findings suggest that TMEM158 may switch from a protective senescence-associated factor to a promoter of tumor progression depending on the molecular environment and accompanying signaling networks. Consequently, TMEM158 has become an important research target in investigations of cancer biology, tumor evolution, and therapeutic resistance.
Beyond oncology, TMEM158 is being explored for potential roles in aging, fibrosis, wound healing, and other conditions involving altered cellular proliferation and tissue remodeling. Its expression profile makes it useful for examining senescence-associated signaling alongside Ras, mitogen-activated protein kinase, cyclin-dependent kinase inhibitors, and extracellular matrix regulatory pathways. Ongoing research continues to clarify how TMEM158 coordinates signaling between the plasma membrane and intracellular pathways that determine cell fate. An TMEM158 Antibody is a valuable research tool for investigating cellular senescence, Ras signaling, cancer progression, and mechanisms governing proliferation, differentiation, and tissue remodeling.
Learn more about antibodies for tumor biology and oncogenic signaling on our Cancer Marker Antibodies page.
Titration of the TMEM158 Antibody / Ras-Induced Senescence Protein 1 Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 186-218 from the human protein was used as the immunogen for the WBP1 antibody.
Aliquot the TMEM158 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
TMEM158 antibody, Ras-Induced Senescence Protein 1 antibody, Transmembrane Protein 158 antibody, RIS1 antibody, BBP antibody
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