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Home >> Antibodies >> TLR5 Antibody

TLR5 Antibody (F44374)

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  Catalog No Formulation Size Price (USD)  
Image F44374-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F44374-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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TLR5 antibody used in western blot to detect TLR5 in HL-60 cell lysate
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TLR5 antibody used in western blot to detect TLR5 in HL-60 cell lysate
IHC analysis of FFPE human breast carcinoma tissue stained with the TLR5 antibody
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt Q9JLF7
Localization Cytoplasmic, membrane
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Limitations This TLR5 antibody is available for research use only.
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Description

TLR5, a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. It also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has an unique TLR5 haplotype and a lower expression of TRL5.

Application Notes

Titration of the TLR5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 71-102 from the mouse protein was used as the immunogen for this TLR5 antibody.

Storage

Aliquot the TLR5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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