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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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TL1A antibody recognizes Tumor necrosis factor ligand superfamily member 15, also known as VEGI, a cytokine encoded by the TNFSF15 gene. TL1A is a type II transmembrane protein belonging to the tumor necrosis factor ligand superfamily and is primarily expressed by endothelial cells and activated immune cells. TL1A Antibody for IHC is developed to detect endogenous VEGI in formalin-fixed, paraffin-embedded tissues for research applications focused on inflammatory signaling and angiogenic regulation.
VEGI functions as a ligand for death receptor 3, also known as TNFRSF25, activating downstream signaling pathways that regulate T cell activation, cytokine production, and apoptosis-associated mechanisms. Through this receptor interaction, TNFSF15 plays a central role in modulating adaptive immune responses, particularly in T helper cell differentiation and effector activity. In addition to immune regulation, TL1A exerts anti-angiogenic effects by inhibiting endothelial cell proliferation and influencing vascular remodeling.
The TNFSF15 gene is located on chromosome 9q32 and encodes a membrane-bound protein that can be proteolytically processed to generate a soluble form. TL1A expression has been documented in vascular endothelium and inflamed tissues, and dysregulated TNFSF15 signaling has been associated with inflammatory bowel disease, autoimmune disorders, and tumor-associated vascular changes. In oncology research, VEGI has been studied for its capacity to suppress tumor angiogenesis by limiting vascular support within the tumor microenvironment.
Because TL1A bridges vascular biology and immune activation, it remains an important target for studies examining endothelial-immune interactions and cytokine-driven inflammation in both normal and disease contexts.
Clone TLRM1-1 is a monoclonal antibody that recognizes TL1A and is suitable for detecting VEGI expression in immunohistochemical analyses of human tissue specimens.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TL1A antibody to be titered up or down for optimal performance.
A full length human recombinant protein was used as the immunogen for this TL1A antibody.
Store the TL1A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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