- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Tissue factor pathway inhibitor 2 Antibody / TFPI2 [clone TFPI2/13027] (V5813)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5813-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5813-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5813SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | TFPI2/13027 |
| Purity | Protein G affinity |
| UniProt | P48307 |
| Localization | Cell membrane, cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This Tissue factor pathway inhibitor 2 antibody is available for research use only. |
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Tissue factor pathway inhibitor 2 antibody, also known as TFPI2 antibody, recognizes Tissue factor pathway inhibitor 2, a secreted Kunitz-type serine protease inhibitor encoded by the TFPI2 gene. TFPI2 is a member of the Kunitz protease inhibitor family and is commonly referred to as placental protein 5 in earlier literature. The protein is synthesized with a signal peptide and secreted into the extracellular space, where it associates with the extracellular matrix and regulates pericellular proteolysis. Tissue factor pathway inhibitor 2 antibody is used to study extracellular matrix remodeling, tumor invasion, and protease-dependent signaling pathways.
TFPI2 contains three tandem Kunitz-type inhibitory domains that enable it to inhibit a range of serine proteases, including plasmin, trypsin, and certain matrix-associated proteases. Through these inhibitory functions, Tissue factor pathway inhibitor 2 modulates extracellular matrix degradation and influences cell migration, angiogenesis, and tissue remodeling. Although structurally related to Tissue factor pathway inhibitor 1, TFPI2 has distinct biochemical properties and primarily functions in the extracellular matrix rather than directly regulating the tissue factor coagulation pathway. Its activity contributes to maintaining tissue integrity by limiting excessive proteolytic activity in the tumor microenvironment and during inflammatory responses.
TFPI2 expression is observed in a variety of tissues, including placenta, vascular endothelium, and epithelial compartments. In many cancers, TFPI2 expression is reduced due to promoter hypermethylation, and this loss has been associated with enhanced invasive potential and poor prognosis. As a result, Tissue factor pathway inhibitor 2 antibody is frequently used in studies evaluating epigenetic regulation, tumor progression, and stromal-epithelial interactions. Because TFPI2 is secreted and matrix-associated, staining patterns are typically extracellular or pericellular in tissue sections. Clone TFPI2/13027 is designed to detect TFPI2 in research applications and supports investigation of extracellular protease regulation and tumor biology.
Optimal dilution of the Tissue factor pathway inhibitor 2 antibody should be determined by the researcher.
A portion of amino acids 100-235 from human TFPI2 protein was used as the immunogen for the Tissue factor pathway inhibitor 2 antibody.
Aliquot the Tissue factor pathway inhibitor 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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