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Home >> Antibodies >> TIMP4 Antibody

TIMP4 Antibody (R30262)

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  Catalog No Formulation Size Price (USD)  
Image R30262 0.2mg/ml in PBS with 50% glycerol and 0.025% sodium azide 100 ug 429
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Western blot testing of TIMP4 antibody and Lane 1: rat kidney; 2: human MCF-7; Predicted/observed molecular weight: ~25 kDa.
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Western blot testing of TIMP4 antibody and Lane 1: rat kidney; 2: human MCF-7; Predicted/observed molecular weight: ~25 kDa.
IHC-P testing of TIMP4 antibody and human breast cancer tissue. HIER: steamed with pH6 citrate buffer.
IHC-P testing of TIMP4 antibody and rat kidney tissue. HIER: steamed with pH6 citrate buffer.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
UniProt Q99727
Localization Secreted
Applications Western blot : 0.5-1ug/ml
Immunohistochemistry (FFPE) : 0.5-1ug/ml
Limitations This TIMP4 antibody is available for research use only.
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Description

The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. The TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the TIMP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

Amino acids 208-224 (YRGHLPLRKEFVDIVQP-human) were used as the immunogen for this TIMP4 antibody.

Storage

Store the TIMP4 antibody at -20oC.

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