- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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TIM3 antibody detects T-cell immunoglobulin and mucin domain-containing protein 3, encoded by the HAVCR2 gene. TIM3 is an inhibitory receptor expressed on T cells, natural killer cells, and myeloid cells, where it regulates immune tolerance and exhaustion. Because TIM3 plays a central role in tumor immunity and autoimmunity, TIM3 antibody is a critical reagent in immunology, oncology, and therapeutic research.
TIM3 is a type I transmembrane protein with an extracellular immunoglobulin domain, a mucin-like stalk, and a cytoplasmic tail that mediates inhibitory signaling. Ligands for TIM3 include galectin-9, phosphatidylserine, and CEACAM1, interactions that dampen T-cell responses and promote immune exhaustion. Dysregulated TIM3 signaling contributes to tumor immune evasion and progression of chronic infections.
The TIM3 antibody clone TIM3/4031 provides specific and reproducible recognition. Clone TIM3/4031 has been cited in peer-reviewed publications addressing T-cell exhaustion, tumor immunology, and checkpoint blockade. Its applications include flow cytometry, immunohistochemistry, and mechanistic studies of immune regulation.
Research using clone TIM3/4031 has demonstrated how TIM3 expression correlates with dysfunctional T cells in cancer and viral infection. Targeting TIM3 is under investigation as a therapeutic strategy, either alone or in combination with PD-1 blockade, to restore antitumor immunity. This antibody enables detection of TIM3 expression patterns, supporting research into immune exhaustion, tolerance, and regulation of autoimmunity.
NSJ Bioreagents provides this TIM3 antibody to support immunology, oncology, and checkpoint biology research. Alternate designations include HAVCR2 antibody, hepatitis A virus cellular receptor 2 antibody, T-cell immunoglobulin and mucin domain 3 antibody, immune checkpoint receptor antibody, and T-cell exhaustion marker antibody.
Optimal dilution of the TIM3 antibody should be determined by the researcher.
A portion of amino acids 22-202 from the human protein was used as the immunogen for the TIM3 antibody.
Store the TIM3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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