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Home >> Antibodies >> TIA1 Antibody / T-Cell Intracellular Antigen-1

TIA1 Antibody / T-Cell Intracellular Antigen-1 (R35053)

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  Catalog No Formulation Size Price (USD)  
Image R35053-100UG 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide 100 ug 449
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Immunofluorescent staining of fixed and permeabilized human HeLa cells with TIA1 antibody (green) at 5ug/ml and DAPI nuclear stain (blue).
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Immunofluorescent staining of fixed and permeabilized human HeLa cells with TIA1 antibody (green) at 5ug/ml and DAPI nuclear stain (blue).
IHC staining of FFPE human thyroid tissue with TIA1 antibody at 3.75ug/ml. Required HIER: steamed antigen retrieval with pH6 citrate buffer; AP-staining.
Western blot testing of Jurkat cell lysate with TIA1 antibody at 0.1ug/ml. Predicted molecular weight: ~43 kDa, ~42 kDa and ~24 kDa (three isoforms).
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (goat origin)
Isotype Goat Ig
Purity Antigen affinity
UniProt P31483
Gene ID 7072
Localization Nuclear, cytoplasmic
Applications Western Blot : 0.1-0.3ug/ml
Immunohistochemistry (FFPE) : 3.75ug/ml
Immunofluorescence : 5ug/ml
ELISA (peptide) LOD : 1:128000
Limitations This TIA1 antibody is available for research use only.
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Description

T-Cell Intracellular Antigen-1 (TIA1) is involved in regulating gene expression and has been found to be essential for the maintenance of T-cell homeostasis. Research has shown that TIA1 is involved in alternative splicing and mRNA degradation, processes that are essential for the proper functioning of T-cells. In addition, TIA1 has been shown to play a role in the regulation of immune responses and inflammation. TIA1 also plays a role in the response to stress. When T-cells are exposed to stress, TIA1 relocalizes to stress granules and helps to regulate the translation of stress-induced mRNAs. This process is essential for the survival of T-cells under stress conditions.

Application Notes

Optimal dilution of the TIA1 antibody should be determined by the researcher.

Immunogen

Amino acids PKSTYESNTKQ were used as the immunogen for this TIA1 antibody.

Storage

Aliquot and store the TIA1 antibody at -20oC.

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