- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Thyroid Transcription Factor PAX8 Antibody / PAX8 [clone PAX8/12570] (V6019)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V6019-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V6019-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V6019SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | PAX8/12570 |
| UniProt | Q06710 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Thyroid Transcription Factor PAX8 antibody is available for research use only. |
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Thyroid Transcription Factor PAX8 antibody recognizes PAX8, a nuclear transcription factor encoded by the PAX8 gene and a key regulator of thyroid epithelial differentiation. PAX8 is a member of the paired box family of transcription factors and plays an essential role in thyroid gland development and function. Because of its central involvement in thyroid lineage specification, PAX8 antibody is widely used in research focused on thyroid biology and thyroid-derived tumors.
PAX8 contains a conserved paired DNA-binding domain that enables regulation of genes critical for follicular cell differentiation. In thyroid epithelial cells, PAX8 activates transcription of genes required for thyroid hormone biosynthesis, including thyroglobulin and thyroid peroxidase. This transcriptional activity supports maintenance of differentiated follicular cell phenotype and hormone production. Detection of PAX8 therefore reflects functional thyroid lineage identity.
Although strongly associated with the thyroid, PAX8 expression is also present in renal tubular epithelial cells and in tissues derived from the Mullerian duct, including the fallopian tube and endometrium. In these tissues, PAX8 contributes to epithelial differentiation and developmental regulation. The protein localizes to the nucleus, consistent with its role as a transcription factor. In pathologic contexts, PAX8 expression is frequently retained in thyroid carcinomas, renal cell carcinomas, and Mullerian-derived tumors, supporting its value in studies evaluating tumor origin and epithelial lineage commitment.
The PAX8 gene is located on chromosome 2q14 and produces multiple isoforms through alternative splicing. Gene rearrangements and dysregulated expression of PAX8 have been implicated in thyroid neoplasia and other malignancies. Thyroid Transcription Factor PAX8 antibody clone PAX8/12570 is a mouse monoclonal antibody developed to detect PAX8 in research applications. Clone PAX8/12570 supports consistent nuclear detection of PAX8 in tissues relevant to thyroid differentiation, renal epithelial biology, and Mullerian-derived tumors.
Optimal dilution of the Thyroid Transcription Factor PAX8 antibody should be determined by the researcher.
A recombinant fragment (around amino acids 50-300) of human PAX8 protein (exact sequence is proprietary) was used as the immunogen for the Thyroid Transcription Factor PAX8 antibody.
Thyroid Transcription Factor PAX8 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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