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Home >> Antibodies >> Thrombomodulin Antibody (C-Terminal Region)

Thrombomodulin Antibody (C-Terminal Region) (F54086)

  Catalog No Formulation Size Price (USD)  
Image F54086-0.2ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.2 ml 359
Image
F54086-0.05ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.05 ml 149
Western blot testing of Thrombomodulin antibody at 1:2000 + human THP1 cell lysate. Expected molecular weight ~60/100 kDa (unmodified/glycosylated).
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P07204
Applications Western Blot : 1:2000
Limitations This Thrombomodulin antibody is available for research use only.
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Description

Thrombomodulin/THBD/TM/CD141 is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. [UniProt]

Application Notes

The stated application concentrations are suggested starting points. Titration of the Thrombomodulin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 537-571 from human THBD was used as the immunogen for the Thrombomodulin antibody.

Storage

Aliquot the Thrombomodulin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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