Thrombomodulin Antibody / Protein C Pathway Receptor [clone THBD/1782] (V3324)

Thrombomodulin Antibody / Protein C Pathway Receptor. Immunohistochemistry analysis of Thrombomodulin / THBD expression in human cervical carcinoma using clone THBD/1782. FFPE tumor tissue shows membranous HRP-DAB brown staining in tumor epithelial cells with additional staining of endothelial cells lining vascular structures, consistent with the known localization of thrombomodulin as a protein C pathway receptor in vascular endothelium. Antigen retrieval was performed by boiling sections in 10mM Tris buffer with 1mM EDTA, pH 9, for 10-20 minutes followed by cooling at room temperature.

Thrombomodulin Antibody / Protein C Pathway Receptor. Immunohistochemistry analysis of Thrombomodulin / THBD expression in human placenta using clone THBD/1782. FFPE placental tissue shows membranous HRP-DAB brown staining along trophoblastic cell membranes and endothelial cells within placental vascular structures, consistent with the known localization of thrombomodulin as a protein C pathway receptor involved in thrombin-dependent anticoagulant signaling in vascular endothelium. Antigen retrieval was performed by boiling sections in 10mM Tris buffer with 1mM EDTA, pH 9, for 10-20 minutes followed by cooling at room temperature.

SDS-PAGE Analysis of Purified, BSA-Free Thrombomodulin Antibody (clone THBD/1782). Confirmation of Integrity and Purity of the Antibody.

Thrombomodulin Antibody / Protein C Pathway Receptor. Specificity validation of clone THBD/1782 using a HuProt(TM) human protein microarray containing more than 19,000 full-length human proteins. The antibody shows highly selective binding to Thrombomodulin / THBD (CD141), the protein C pathway receptor, with the strongest signal on the array and minimal cross-reactivity with other proteins, supporting the exceptional specificity of the THBD/1782 monoclonal antibody.
Z- and S-score interpretation: The Z-score represents the strength of the fluorescent signal produced when the antibody binds to a specific protein on the HuProt(TM) array and is expressed as the number of standard deviations above the mean signal intensity of all proteins on the array. Proteins are ranked according to descending Z-scores. The S-score represents the difference between consecutive Z-scores and therefore reflects the relative specificity of the antibody for its intended target compared with other proteins on the array.