- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Thomsen-Friedenreich Antigen Antibody / CD176 [clone A84-A/F10] (V8325)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8325-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 519 | |
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V8325-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 229 | |
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V8325SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 519 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgM, kappa |
| Clone Name | A84-A/F10 |
| Purity | PEG precipitation |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Thomsen-Friedenreich Antigen antibody is available for research use only. |
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Recognizes a disaccharide epitope, Gal 1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF , including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The TF antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. Considered to be a pan-carcinoma marker. It is capable to agglutinate desialylated red blood cells. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. It is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. TF antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. Its presence on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.
Optimal dilution of the Thomsen-Friedenreich Antigen antibody should be determined by the researcher.
Neuraminidase-treated human red blood cells were used as the immunogen for this Thomsen-Friedenreich Antigen antibody.
Store the Thomsen-Friedenreich Antigen antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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