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Home >> Antibodies >> Thioredoxin-interacting protein Antibody / TXNIP

Thioredoxin-interacting protein Antibody / TXNIP (RQ8613)

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  Catalog No Formulation Size Price (USD)  
Image RQ8613 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 439
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Flow cytometry testing of fixed and permeabilized human MCF7 cells with Thioredoxin-interacting protein antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Thioredoxin-interacting protein antibody.
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Flow cytometry testing of fixed and permeabilized human MCF7 cells with Thioredoxin-interacting protein antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= Thioredoxin-interacting protein antibody.
Western blot testing of 1) human K562, 2) human MCF7, 3) rat brain, 4) rat testis and 5) mouse brain tissue lysate with Thioredoxin-interacting protein antibody. Predicted molecular weight: ~44 kDa and ~37 kDa (two isoforms).
Availability 1-3 days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt Q9H3M7
Applications Western Blot : 0.5-1ug/ml
Flow Cytometry : 1-3ug/million cells
ELISA : 0.1-0.5ug/ml
Limitations This Thioredoxin-interacting protein antibody is available for research use only.
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Description

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the Thioredoxin-interacting protein antibody should be determined by the researcher.

Immunogen

An E.coli-derived human recombinant protein (amino acids D122-N152) was used as the immunogen for the Thioredoxin-interacting protein antibody.

Storage

After reconstitution, the Thioredoxin-interacting protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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