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- Tel: 858.663.9055
- Email: info@nsjbio.com
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TH-POK (T-helper-inducing POZ/Kr ppel-like factor), also known as zinc finger protein 67 (ZFP67), zinc finger and BTB domain-containing protein 7B or Kr ppel-related zinc finger protein cKrox, is a 539 amino acid protein that contains one BTB (POZ) domain and four C2H2-type zinc fingers. Localized to the nucleus, TH-POK functions primarily as a key regulator of lineage commitment of immature T-cell precursors. Specifically, the presence of TH-POK directs positively selected thymocytes to the CD4 lineage, whereas its absence causes default development to the CD8 lineage. TH-POK also functions as a transcriptional repressor of various other genes, such as COL1A1, COL1A2 and Fibronectin.
Optimal dilution of the Th-Pok antibody should be determined by the researcher.
Recombinant full-length human Zinc finger and BTB domain-containing protein 7B protein was used as the immunogen for the Th-Pok antibody.
Aliquot the Th-Pok antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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