- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TGOLN2 Antibody / Trans-Golgi network integral membrane protein 2 (FY12425)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12425 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
The TGOLN2 antibody targets Trans-Golgi network integral membrane protein 2, also known as TGN46, encoded by the TGOLN2 gene. This type I transmembrane glycoprotein localizes to the trans-Golgi network (TGN), where it participates in protein sorting, trafficking, and recycling between the Golgi apparatus and endosomes. Trans-Golgi network integral membrane protein 2 acts as a marker of the TGN and is essential for maintaining Golgi structure and vesicle organization. The TGOLN2 antibody provides a robust reagent for studying Golgi dynamics, membrane transport, and secretory-pathway regulation.
Trans-Golgi network integral membrane protein 2 cycles between the TGN and plasma membrane via clathrin-coated vesicles, controlling cargo retrieval and receptor recycling. Its luminal domain carries O-linked glycosylation sites that modulate trafficking efficiency. The TGOLN2 antibody allows visualization of this dynamic localization pattern, offering a reliable marker for confocal microscopy and subcellular fractionation studies. Its expression is ubiquitous in secretory cells, particularly in liver, pancreas, and neurons.
TGN46 functions as a sorting receptor for a subset of secreted and membrane proteins, ensuring their correct targeting to the cell surface or lysosomes. The TGOLN2 antibody supports mechanistic research into Golgi transport, revealing how membrane trafficking contributes to cellular polarity and secretion. Through its cytoplasmic tail, TGN46 interacts with adaptor protein complexes (AP-1 and GGA), linking it to clathrin-mediated sorting pathways.
Aberrant Golgi organization is a hallmark of many diseases, including neurodegenerative disorders and cancers. The TGOLN2 antibody is widely used as a Golgi marker in pathology and cell-biology research, helping identify structural changes associated with altered vesicular transport. Changes in TGN46 distribution can reflect stress-induced fragmentation or disrupted trafficking in diseased cells.
The TGOLN2 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, yielding strong perinuclear staining that defines Golgi morphology. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for studies of membrane trafficking, organelle architecture, and protein secretion. By enabling accurate detection of Trans-Golgi network integral membrane protein 2, the TGOLN2 antibody advances research into the organization and dynamics of the Golgi apparatus and secretory pathway.
Optimal dilution of the TGOLN2 antibody should be determined by the researcher.
E.coli-derived human TGN46/TGOLN2 recombinant protein (Position: E319-K436) was used as the immunogen for the TGOLN2 antibody.
After reconstitution, the TGOLN2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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