- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TGFBI Antibody / Transforming growth factor-beta-induced protein ig-h3 (FY12406)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12406 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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The TGFBI antibody targets Transforming growth factor-beta-induced protein ig-h3, a secreted extracellular matrix protein encoded by the TGFBI gene. Induced by TGF-beta signaling, this protein plays critical roles in cell adhesion, migration, and matrix organization. Transforming growth factor-beta-induced protein ig-h3 contains multiple fasciclin domains that mediate interactions with integrins and collagen, promoting tissue integrity and repair. The TGFBI antibody provides a valuable tool for studying extracellular signaling, wound healing, and fibrotic disease mechanisms.
Transforming growth factor-beta-induced protein ig-h3 is secreted into the extracellular space, where it binds integrins such as alphavbeta3 and alpha3beta1 to regulate adhesion and cell-matrix communication. It is widely expressed in corneal, epithelial, and connective tissues. The TGFBI antibody allows visualization of its distribution and quantification under TGF-beta stimulation, providing insight into how this protein orchestrates matrix remodeling. Its RGD motif facilitates integrin binding, influencing cell attachment, migration, and differentiation.
Mutations in the TGFBI gene cause a spectrum of hereditary corneal dystrophies, including granular, lattice, and Avellino types, characterized by amyloid or hyaline deposits in the cornea. The TGFBI antibody supports studies into these pathologies, enabling detection of protein accumulation and abnormal deposition patterns. By tracking misfolded Transforming growth factor-beta-induced protein ig-h3, researchers can better understand disease progression and potential therapeutic interventions aimed at preventing protein aggregation.
Beyond ocular disease, TGFBI is implicated in cancer, fibrosis, and tissue regeneration. It may function as either a tumor suppressor or promoter depending on context, influencing epithelial-to-mesenchymal transition (EMT) and extracellular matrix stiffness. The TGFBI antibody supports exploration of these dual roles by enabling quantification of expression levels in tumor microenvironments and fibrotic tissues. TGFBI overexpression is associated with enhanced metastasis in certain cancers, making it a potential biomarker for disease progression.
The TGFBI antibody performs well in western blotting, immunohistochemistry, and immunofluorescence, showing distinct extracellular and pericellular staining consistent with matrix localization. NSJ Bioreagents provides this antibody as a validated reagent with reproducible specificity across model systems. By supporting detailed study of Transforming growth factor-beta-induced protein ig-h3, the TGFBI antibody advances understanding of matrix biology, TGF-beta signaling, and the molecular mechanisms driving fibrosis and corneal dystrophy.
Optimal dilution of the TGFBI antibody should be determined by the researcher.
E.coli-derived human BIGH3/TGFBI recombinant protein (Position: K27-H683) was used as the immunogen for the TGFBI antibody.
After reconstitution, the TGFBI antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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