- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TGFB Antibody / Transforming growth factor beta [clone TGFB/7230] (V4619)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4619-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4619-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4619SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2, kappa |
| Clone Name | TGFB/7230 |
| Purity | Protein A/G affinity |
| UniProt | P01137 |
| Localization | Cytoplasm, Extracellular (secreted) |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This TGFB/Transforming growth factor beta antibody is available for research use only. |
|
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TGFB antibody, also known as Transforming growth factor beta antibody, recognizes a secreted cytokine belonging to the TGF beta superfamily that regulates cell proliferation, differentiation, immune modulation, and extracellular matrix remodeling. Transforming growth factor beta, encoded by TGFB genes including TGFB1, TGFB2, and TGFB3, is synthesized as a precursor protein that undergoes proteolytic processing to generate a mature, biologically active homodimer. This cytokine is widely expressed and functions as a critical regulator of tissue homeostasis, development, and repair.
Transforming growth factor beta is secreted as part of a latent complex that requires activation before receptor engagement. Once activated, TGF beta binds to type II TGF beta receptors, which recruit and phosphorylate type I receptors. This receptor complex initiates intracellular signaling primarily through SMAD transcription factors. Phosphorylated SMAD proteins form complexes that translocate to the nucleus and regulate transcription of genes involved in cell cycle arrest, differentiation, extracellular matrix production, and immune regulation. In addition to canonical SMAD signaling, TGF beta can activate non canonical pathways including MAPK, PI3K-AKT, and Rho like GTPase signaling cascades.
In normal physiology, Transforming growth factor beta plays a central role in embryogenesis, angiogenesis, and wound healing. It maintains immune tolerance by promoting regulatory T cell differentiation and suppressing inflammatory responses. Dysregulated TGFB signaling has been implicated in fibrotic diseases, chronic inflammation, and tumor progression. In early stages of tumorigenesis, TGF beta often acts as a tumor suppressor by inhibiting epithelial cell proliferation. However, in advanced cancers, it can promote epithelial to mesenchymal transition, invasion, metastasis, and immune evasion within the tumor microenvironment.
Because of its pleiotropic biological functions, TGFB antibody is widely used in research investigating fibrosis pathways, immune modulation, and cancer biology. Detection of Transforming growth factor beta expression supports studies focused on cytokine signaling networks and tissue remodeling processes. A TGFB antibody is suitable for research applications aimed at evaluating TGFB expression in normal and disease related contexts.
TGFB/Transforming growth factor beta antibody (clone TGFB/7230) recognizes TGF beta 1, 2 and 3.
Optimal dilution of the TGFB/Transforming growth factor beta antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 200-390) from the human TGFB1 protein was used as the immunogen for the TGFB/Transforming growth factor beta antibody.
Aliquot the TGFB/Transforming growth factor beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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