TG2 Antibody / Tissue Transglutaminase Antibody (R34793)

Description

TG2 Antibody / Tissue Transglutaminase Antibody recognizes tissue transglutaminase (TG2), also known as Transglutaminase 2 (TGM2), a multifunctional enzyme that catalyzes calcium-dependent protein crosslinking while also serving important structural and signaling roles. TG2 is broadly expressed in epithelial, endothelial, stromal, and immune cells and is present within both the cytoplasm and extracellular matrix. Beyond its enzymatic activity, Tissue Transglutaminase functions as a GTP-binding protein and signaling scaffold that regulates cell adhesion, migration, survival, and tissue remodeling. A TG2 Antibody / Tissue Transglutaminase Antibody provides a valuable tool for studying TG2 expression in normal physiology and disease.

Tissue Transglutaminase plays a central role in extracellular matrix organization through interactions with fibronectin, integrins, collagen, and other matrix proteins. These activities influence wound healing, fibrosis, cellular differentiation, apoptosis, and responses to tissue injury. TG2 is also recognized as the principal autoantigen in celiac disease and has been implicated in tumor progression, metastatic behavior, therapeutic resistance, cardiovascular disease, and chronic inflammatory disorders. Diminished or excessive TG2 activity can significantly alter tissue architecture and cellular signaling, making it an important focus of translational research.

TG2 antibodies are suitable for applications including Western blotting, immunohistochemistry, immunofluorescence, flow cytometry, immunoprecipitation, and related protein detection methods when validated for the specific application. Appropriate experimental controls remain important because Tissue Transglutaminase may exist in multiple conformational states and cellular compartments. NSJ Bioreagents provides carefully validated antibodies to support investigations of cell adhesion, extracellular matrix remodeling, fibrosis, autoimmune disease, and cancer biology. A TG2 Antibody / Tissue Transglutaminase Antibody is a valuable research reagent for detecting Tissue Transglutaminase and advancing studies of extracellular matrix organization, cellular signaling, and disease-associated tissue remodeling.

Visit our TGM2 Antibody / Transglutaminase 2 Antibody page to explore additional validated antibodies and research tools for investigating TGM2 expression, extracellular matrix remodeling, cell adhesion, fibrosis, and cancer progression.

Application Notes

Optimal dilution of the TG2 Antibody / Tissue Transglutaminase Antibody should be determined by the researcher.

1. This TG2 antibody is specific for isoform a.

Immunogen

Amino acids NFESDKLKAVKGFR were used as the immunogen for this TG2 antibody. This sequence is specific to isoform a.

Storage

Aliquot and store the TG2 antibody at -20oC.

Alternate Names

TG2 antibody, Tissue Transglutaminase antibody, TGM2 antibody, Transglutaminase 2 antibody, Protein-glutamine Gamma-glutamyltransferase 2 antibody, Transglutaminase C antibody