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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Tetherin Antibody / BST2 (RQ7154)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7154 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q10589 |
| Applications | Western Blot : 0.5-1ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This Tetherin antibody is available for research use only. |
|
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Tetherin antibody, also known as BST2 antibody, recognizes Bone marrow stromal antigen 2, a type II transmembrane protein encoded by the human BST2 gene located on chromosome 19p13.2. Tetherin is an interferon-inducible antiviral restriction factor that localizes to the plasma membrane, endosomes, and the trans-Golgi network. BST2 is widely referred to in the literature as Tetherin, CD317, and HM1.24. Tetherin antibody is commonly used in research examining innate immunity, viral restriction, and interferon signaling pathways.
Bone marrow stromal antigen 2 contains a short N-terminal cytoplasmic tail, a transmembrane domain, an extracellular coiled-coil region, and a C-terminal glycosylphosphatidylinositol anchor. This unique topology allows Tetherin to anchor both to the host cell membrane and to budding viral envelopes, physically tethering virions to the cell surface and preventing viral release. BST2 expression is strongly upregulated by type I interferons, linking its function to antiviral defense mechanisms. Tetherin antibody supports investigation of host-virus interactions and innate immune responses.
Tetherin is broadly expressed in immune cells including B lymphocytes, plasmacytoid dendritic cells, and activated T cells, as well as in epithelial tissues under inflammatory conditions. It has been extensively studied in the context of HIV-1, where viral proteins such as Vpu counteract BST2 to promote viral particle release. In addition to antiviral roles, BST2 has been implicated in immune signaling, NF-kappaB activation, and regulation of cytokine production. Tetherin antibody is therefore frequently applied in studies of viral pathogenesis and immune regulation.
Beyond infectious disease research, CD317 expression has been reported in multiple myeloma and other hematologic malignancies, where it serves as a surface marker in research settings. Tetherin antibody enables detection of membrane-associated BST2 and supports studies of antiviral defense, interferon biology, and immune cell activation.
Optimal dilution of the Tetherin antibody should be determined by the researcher.
Recombinant human protein (amino acids N49-S161) was used as the immunogen for the Tetherin antibody.
After reconstitution, the Tetherin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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