- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Tenascin C Antibody T2H5 / Cytotactin Antibody [clone T2H5] (V2602)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2602-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V2602-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V2602SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V2602IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | T2H5 |
| Purity | Protein G affinity chromatography |
| UniProt | P24821 |
| Localization | Connective tissue matrix |
| Applications | Immunohistochemistry (FFPE) : 2-4ug/ml for 30 min at RT |
| Limitations | This Tenascin C Antibody T2H5 / Cytotactin Antibody is available for research use only. |
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Tenascin C Antibody T2H5 / Cytotactin Antibody recognizes Tenascin C (TNC), a large extracellular matrix glycoprotein involved in tissue organization, cell adhesion, migration, and signaling. Tenascin C, historically known as cytotactin and hexabrachion, forms a characteristic disulfide-linked hexamer and contains multiple structural domains that mediate interactions with extracellular matrix components, cell-surface receptors, and other proteins. Its highly regulated expression distinguishes Tenascin C from many constitutively expressed components of the extracellular matrix.
Tenascin C is particularly prominent during embryonic development, where it is associated with sites of active tissue remodeling and mesenchymal-epithelial interactions. Expression is substantially more restricted in most normal adult tissues but can increase following tissue injury, inflammation, and other conditions involving extracellular matrix remodeling. Through interactions with integrins, fibronectin, and additional extracellular molecules, TNC can influence cell adhesion, migration, proliferation, and the organization of the surrounding matrix.
Tenascin C has also received considerable attention in cancer biology because its expression is frequently elevated within the tumor microenvironment. Increased TNC can occur in the stromal and neovascular compartments of diverse tumors and has been investigated in relation to tumor progression, angiogenesis, invasion, and remodeling of the extracellular matrix. These characteristics have made Tenascin C an important marker for studying tumor-associated stroma as well as the dynamic interactions between malignant cells and their surrounding extracellular environment.
Alternative splicing generates multiple Tenascin C isoforms that differ in the number of fibronectin type III domains incorporated into the mature protein. These isoforms contribute to substantial variation in molecular size and may display differences in tissue distribution and biological activity. Clone T2H5 recognizes Tenascin C and has historically been reported to detect approximately 210 kDa and 300 kDa forms of the protein. Specificity of the monoclonal antibody has also been evaluated by sequential immunoprecipitation using a polyclonal antibody against Tenascin C.
NSJ Bioreagents offers this Cytotactin Antibody for research into extracellular matrix organization and Tenascin C biology. A Tenascin C Antibody can support investigation of TNC expression in developmental biology, tissue remodeling, tumor-associated stroma, and other processes involving dynamic changes in the extracellular matrix.
Explore our Cancer Marker Antibodies page for additional reagents targeting proteins associated with tumor biology, angiogenesis, extracellular matrix remodeling, and cancer progression.
Optimal dilution of the Tenascin C Antibody T2H5 / Cytotactin Antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Human breast carcinoma cells were used as the immunogen for the Tenascin C Antibody T2H5.
Store the Tenascin C Antibody T2H5 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
TNC antibody, Tenascin C antibody, Tenascin-C antibody, Cytotactin antibody, Hexabrachion antibody, Tenascin antibody
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