- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TARDBP Antibody Mouse Monoclonal / TAR DNA binding protein / TDP43 [clone TARDP/349] (V4706)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4706-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4706-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4706SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1 |
| Clone Name | TARDP/349 |
| Purity | Protein A/G affinity |
| UniProt | Q13148 |
| Localization | Nucleus |
| Applications | ELISA (Order BSA-free Format For Coating) : Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This TARDBP antibody is available for research use only. |
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TARDBP antibody recognizes TAR DNA binding protein 43, commonly known as TDP-43, a ubiquitously expressed nuclear RNA- and DNA-binding protein encoded by the TARDBP gene. TDP-43 is predominantly localized to the nucleus under physiological conditions, where it regulates transcription, alternative splicing, RNA stability, and microRNA processing. TARDBP Antibody Mouse Monoclonal is developed to detect endogenous TAR DNA binding protein 43 in research applications focused on RNA metabolism and neurodegenerative disease mechanisms.
TDP-43 contains two RNA recognition motifs that bind UG-rich RNA sequences and a C-terminal glycine-rich domain that mediates protein-protein interactions. Through these structural domains, TARDBP controls the processing and transport of numerous transcripts critical for neuronal development, synaptic maintenance, and cellular stress responses. In addition to its nuclear functions, TDP-43 shuttles between the nucleus and cytoplasm and can localize to stress granules during cellular stress conditions.
The TARDBP gene is located on chromosome 1p36.22 and produces multiple isoforms through alternative splicing. Under pathologic conditions, TDP-43 may undergo abnormal cytoplasmic redistribution, hyperphosphorylation, ubiquitination, and proteolytic cleavage. Aggregated forms of TAR DNA binding protein 43 are a defining neuropathologic hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Both loss of normal nuclear function and toxic cytoplasmic aggregation are believed to contribute to neuronal dysfunction and cell death.
Beyond neurodegeneration, TARDBP has been implicated in cancer biology, inflammation, and viral replication, reflecting its broad role in gene expression regulation. Altered TDP-43 expression or localization may influence apoptosis pathways, cell cycle progression, and RNA regulatory networks across multiple tissue types.
Clone TARDP/349 is a mouse monoclonal antibody that recognizes TAR DNA binding protein 43 and supports studies of nuclear RNA regulation, stress granule biology, and TDP-43-associated disease pathology.
Optimal dilution of the TARDBP antibody should be determined by the researcher.
A recombinant fragment from the human protein (within amino acids 200-414) was used as the immunogen for the TARDBP antibody.
Aliquot the TARDBP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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