- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TARDBP Antibody / TAR DNA binding protein / TDP43 (RQ8739)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8739 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity chromatography |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q13148 |
| Localization | Nuclear, cytoplasmic |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells ELISA : 0.1-0.5ug/ml Immunoprecipitation : 2ug per 500ug of lysate |
| Limitations | This TARDBP antibody is available for research use only. |
|
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TARDBP antibody targets TAR DNA binding protein 43 (TARDBP), also known as TDP-43, a ubiquitously expressed RNA-binding protein that regulates multiple aspects of RNA metabolism. TARDBP localizes predominantly to the nucleus under basal conditions, with dynamic shuttling to the cytoplasm in response to cellular signaling and stress. The protein contains two RNA recognition motifs and a glycine-rich C-terminal domain that together enable binding to RNA and DNA targets involved in transcription, pre-mRNA splicing, RNA transport, and stability. Through these activities, TARDBP plays a central role in post-transcriptional gene regulation.
Functionally, TARDBP binds UG-rich RNA sequences and influences alternative splicing decisions, transcript maturation, and mRNA turnover across a wide range of genes. TARDBP expression is broadly detected across tissues, reflecting its fundamental role in maintaining normal cellular gene expression programs. The protein also participates in autoregulatory feedback loops that control its own mRNA levels, helping maintain appropriate intracellular TARDBP abundance. A TARDBP antibody supports studies examining RNA processing and gene expression control in diverse biological contexts.
TARDBP is highly dynamic and responsive to cellular stress. Under conditions such as oxidative stress or impaired RNA metabolism, TARDBP can redistribute to the cytoplasm and associate with stress granules, reflecting its involvement in adaptive RNA handling pathways. Persistent mislocalization or altered regulation of TARDBP disrupts RNA homeostasis and can affect cell viability. These features highlight the importance of tightly controlled TARDBP localization and function for cellular health and stress adaptation.
From a biological and disease-relevance perspective, TARDBP is extensively studied for its involvement in neurodegenerative disorders, where abnormal aggregation and cytoplasmic accumulation of TARDBP are hallmark features. Dysregulation of TARDBP-dependent RNA processing has been linked to altered neuronal gene expression and impaired cellular resilience. Beyond the nervous system, TARDBP also contributes to RNA regulatory networks in muscle, immune, and epithelial cells, underscoring its broad functional relevance.
At the molecular level, TARDBP is encoded by the TARDBP gene and produces a protein of approximately 414 amino acids. The proteinâs RNA recognition motifs mediate sequence-specific RNA binding, while the C-terminal region supports protein-protein interactions and functional regulation. TARDBP activity is influenced by post-translational modifications and cellular localization dynamics. A TARDBP antibody supports research applications focused on RNA biology, post-transcriptional regulation, and cellular stress responses, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the TARDBP antibody should be determined by the researcher.
An E.coli-derived human recombinant protein (amino acids M1-H264) was used as the immunogen for the TARDBP antibody.
After reconstitution, the TARDBP Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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