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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.
Optimal dilution of the TAL1 antibody should be determined by the researcher.
A recombinant human full-length TAL1 protein was used as the immunogen for the TAL1 antibody.
Store the TAL1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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