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Home >> Antibodies >> TAL1 Antibody / T-cell acute lymphocytic leukemia protein 1

TAL1 Antibody / T-cell acute lymphocytic leukemia protein 1 [clone BTL73] (V8109)

  Catalog No Formulation Size Price (USD)  
Image V8109-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8109-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8109SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Bulk quote request
SDS-PAGE analysis of purified, BSA-free TAL1 antibody (clone BTL73) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name BTL73
Purity Protein G affinity chromatography
UniProt P17542
Applications Western blot : 1-2ug/ml
Limitations This TAL1 antibody is available for research use only.
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Description

Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.

Application Notes

Optimal dilution of the TAL1 antibody should be determined by the researcher.

Immunogen

A recombinant human full-length TAL1 protein was used as the immunogen for the TAL1 antibody.

Storage

Store the TAL1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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