- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SYP Antibody Recombinant Mouse MAb Clone rSYP/8807 / Synaptophysin (SYP) Antibody [clone rSYP/8807] (V5331)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5331-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5331-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5331SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rSYP/8807 |
| Purity | Protein A/G affinity |
| UniProt | P08247 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This SYP antibody is available for research use only. |
|
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Synaptophysin (SYP) is a major synaptic vesicle membrane glycoprotein that is highly enriched in presynaptic terminals of neurons throughout the central and peripheral nervous systems. SYP Antibody Recombinant Mouse MAb Clone rSYP/8807 is used in research focused on neuronal connectivity and synaptic vesicle organization, where detection of Synaptophysin provides a reliable marker of presynaptic structures and synapse-rich regions of neural tissue. Because synaptic vesicles accumulate at neuronal terminals prior to neurotransmitter release, SYP is widely used to visualize synaptic density and neuronal network architecture.
Synaptophysin is also referred to in the literature as synaptic vesicle glycoprotein p38 or major synaptic vesicle protein p38 and is encoded by the SYP gene. The protein contains four transmembrane domains that anchor it within synaptic vesicle membranes and help organize vesicle membrane structure. Through interactions with vesicle-associated proteins involved in membrane fusion and neurotransmitter release, Synaptophysin contributes to synaptic vesicle trafficking and vesicle recycling within presynaptic compartments.
Within neurons, Synaptophysin localizes predominantly to presynaptic boutons along axons where clusters of synaptic vesicles accumulate in preparation for neurotransmitter release. Because of this highly specific localization, detection of SYP allows researchers to identify presynaptic terminals and to examine the distribution of synapses within neuronal circuits. Visualization of Synaptophysin-positive vesicles is commonly used to evaluate synapse formation, synaptic remodeling, and changes in synaptic density associated with neuronal development or neurological disease.
Clone rSYP/8807 is a recombinant mouse monoclonal antibody developed to recognize Synaptophysin protein in neuronal tissue. Recombinant monoclonal antibodies provide defined antibody sequences and consistent target recognition, supporting reliable detection of vesicle-associated proteins across experimental studies. Clone rSYP/8807 recognizes the Synaptophysin protein present in synaptic vesicle membranes and enables investigation of synaptic vesicle protein expression in neuronal cells and brain tissue.
Synaptophysin expression is abundant in brain regions that contain dense neuronal synapses including the cerebral cortex, hippocampus, cerebellum, and spinal cord. These regions contain extensive networks of synaptic connections where vesicle-mediated neurotransmitter release is essential for neuronal signaling. Because of this expression pattern, SYP detection is frequently used to evaluate synapse-rich neuropil regions and to study neuronal circuitry in experimental models of brain function.
Due to its tight association with synaptic vesicle membranes and presynaptic terminals, Synaptophysin remains one of the most widely used markers for studying synaptic vesicle biology and neuronal communication. Detection of SYP using clone rSYP/8807 supports research investigating synaptic organization, neuronal connectivity, and vesicle trafficking mechanisms in neuroscience studies.
Optimal dilution of the SYP antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 224-313) from the human protein was used as the immunogen for the SYP antibody.
Aliquot the SYP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Synaptophysin antibody, Synaptic vesicle glycoprotein antibody, Major synaptic vesicle protein p38 antibody, Synaptophysin p38 antibody
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