- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Synaptophysin Antibody Recombinant Rabbit MAb Clone BGB-19 / Synaptophysin (SYP) Antibody [clone BGB-19] (RQ5210)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5210 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
| Availability | 1-2 weeks |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Host | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | BGB-19 |
| Purity | Affinity purified |
| UniProt | P08247 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 1:1000-1:2000 Immunohistochemistry (FFPE) : 1:50-1:200 |
| Limitations | This Synaptophysin antibody is available for research use only. |
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Synaptophysin (SYP) is a synaptic vesicle membrane glycoprotein that plays a central role in neuronal communication and synaptic transmission. Synaptophysin Antibody Recombinant Rabbit MAb Clone BGB-19 is used to detect SYP protein in studies focused on brain tissue and neuronal signaling, where Synaptophysin serves as one of the most widely used molecular markers of presynaptic vesicles. Because synaptic vesicles are densely concentrated within neuronal synapses, detection of SYP allows researchers to examine synapse-rich regions and evaluate neuronal network organization within the brain.
Synaptophysin is also known as synaptic vesicle glycoprotein p38 or major synaptic vesicle protein p38 and is encoded by the SYP gene. The protein contains four transmembrane domains that anchor it within synaptic vesicle membranes, enabling it to function as a structural component of vesicle membranes involved in neurotransmitter storage and release. Through interactions with proteins associated with vesicle fusion and exocytosis, Synaptophysin contributes to the regulation of synaptic vesicle trafficking and neurotransmitter release at neuronal synapses.
In the brain, Synaptophysin is highly enriched within presynaptic terminals of neurons where synaptic vesicles accumulate prior to neurotransmitter release. These presynaptic vesicle clusters are especially abundant within neuronal processes that form complex synaptic networks throughout the cerebral cortex, hippocampus, cerebellum, and other brain regions. Because of this localization, SYP is frequently used as a molecular indicator of synaptic density and neuronal connectivity in studies investigating brain development, neural circuitry, and neurological disease.
Clone BGB-19 is a recombinant rabbit monoclonal antibody developed to recognize Synaptophysin protein in neuronal tissue. Recombinant rabbit monoclonal antibodies are widely used in neuroscience research due to their strong target recognition and consistent performance in detecting neuronal proteins. Clone BGB-19 recognizes Synaptophysin present in synaptic vesicle membranes and supports investigation of synaptic vesicle protein expression in neuronal cells and brain tissue.
Synaptophysin expression is abundant throughout the central nervous system, reflecting the widespread distribution of synapses required for neuronal communication. High levels of SYP are found in regions of the brain containing dense synaptic networks, including the cerebral cortex, hippocampus, cerebellum, and brainstem. Because these regions contain large numbers of synaptic vesicles, Synaptophysin detection is commonly used to evaluate synapse-rich neuropil and to study neuronal signaling pathways within brain tissue.
Due to its strong association with synaptic vesicle membranes and presynaptic terminals, Synaptophysin remains one of the most widely studied proteins in neuroscience. Detection of SYP using Synaptophysin Antibody Recombinant Rabbit MAb Clone BGB-19 supports investigation of neuronal connectivity, synaptic vesicle organization, and mechanisms of synaptic transmission in experimental models of brain function and neurological disease.
Optimal dilution of the Synaptophysin Antibody Recombinant Rabbit MAb Clone BGB-19 should be determined by the researcher.
A synthetic peptide specific to human Synaptophysin / SYP was used as the immunogen for the Synaptophysin antibody.
Store the Synaptophysin antibody at -20oC.
SYP antibody, Synaptic vesicle glycoprotein antibody, Major synaptic vesicle protein p38 antibody, Synaptophysin p38 antibody
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