- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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SUZ12 Antibody / Polycomb Repressive Complex 2 Antibody recognizes SUZ12, an essential core component of Polycomb Repressive Complex 2 (PRC2), a highly conserved chromatin-modifying complex that regulates epigenetic gene silencing through trimethylation of histone H3 lysine 27. Together with EZH2, EED, and additional accessory proteins, SUZ12 is required for PRC2 assembly, enzymatic activity, and stable association with chromatin. This complex plays a central role in maintaining transcriptionally repressed chromatin states during development, stem cell maintenance, and cellular differentiation. NSJ Bioreagents provides SUZ12 Antibody / Polycomb Repressive Complex 2 Antibody for researchers investigating epigenetic regulation and chromatin biology.
SUZ12 is predominantly localized within the nucleus, where it contributes to the establishment and maintenance of repressive chromatin domains that regulate developmental genes and lineage-specific transcriptional programs. By supporting PRC2-mediated histone methylation, SUZ12 helps control cell fate decisions, proliferation, and genome stability. Loss or dysregulation of SUZ12 disrupts normal epigenetic regulation and can alter expression of numerous genes involved in differentiation and tissue homeostasis. An SUZ12 Antibody is therefore valuable for studies of chromatin remodeling, transcriptional repression, and nuclear protein complexes.
Aberrant SUZ12 expression or mutation has been associated with multiple cancers, developmental disorders, and diseases involving epigenetic dysfunction. Altered PRC2 activity contributes to tumor progression, stem cell phenotypes, and changes in lineage commitment, making SUZ12 an important biomarker and research target in oncology and developmental biology. Continued investigation of SUZ12 also provides insight into mechanisms governing chromatin organization and long-term transcriptional memory.
A SUZ12 Antibody is a valuable research tool for investigating Polycomb Repressive Complex 2 function, epigenetic gene silencing, histone methylation, chromatin remodeling, nuclear protein complexes, and transcriptional regulation.
Explore our Transcription Factor Antibodies page to discover additional antibodies for investigating epigenetic regulation, chromatin-associated proteins, nuclear signaling, and gene expression control.
Optimal dilution of the SUZ12 Antibody / Polycomb Repressive Complex 2 Antibody should be determined by the researcher.
A human recombinant protein (amino acids K72-K483) was used as the immunogen for the SUZ12 antibody.
After reconstitution, the SUZ12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
SUZ12 antibody, Polycomb Repressive Complex 2 antibody, SUZ12 Polycomb Repressive Complex 2 Subunit antibody
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