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Home >> Antibodies >> SUV39H2 Antibody (KMT1B)

SUV39H2 Antibody (KMT1B) (F42487)

  Catalog No Formulation Size Price (USD)  
Image F42487-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 329
Image
F42487-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 135
Western blot analysis of lysate from 1) HepG2 and 2) HUVEC cell line using SUV39H2 antibody at 1:1000.
Western blot testing of SUV39H2 antibody and mouse kidney tissue lysate
IHC analysis of FFPE human breast carcinoma tissue stained with the SUV39H2 antibody
Availability 1-3 business days
Species Reactivity Human, Mouse
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt Q9H5I1
Applications Western blot : 1:1000
IHC (Paraffin) : 1:50-1:100
Limitations This SUV39H2 antibody is available for research use only.
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Description

The murine gene Suv39h2/kmt1b encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

Application Notes

Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 93-122 from the human protein was used as the immunogen for this KMT1B / SUV39H2 antibody.

Storage

Aliquot the SUV39H2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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