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Home >> Antibodies >> SUV39H2 Antibody

SUV39H2 Antibody (F47078)

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  Catalog No Formulation Size Price (USD)  
Image F47078-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F47078-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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SUV39H2 antibody western blot analysis in MDA-MB453 lysate. Expected molecular weight: 40-53 kDa.
SUV39H2 antibody western blot analysis in MDA-MB453 lysate. Expected molecular weight: 40-53 kDa.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Primate
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q9H5I1
Applications Western blot : 1:1000
Limitations This SUV39H2 antibody is available for research use only.
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Description

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.

Application Notes

Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 367-395 from the human protein was used as the immunogen for this SUV39H2 antibody.

Storage

Aliquot the SUV39H2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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