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Home >> Antibodies >> Survivin Antibody / BIRC5

Survivin Antibody / BIRC5 [clone DGD-2] (RQ4769)

  Catalog No Formulation Size Price (USD)  
Image RQ4769 Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA 100 ul 429
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IHC staining of FFPE human ovarian cancer with BIRC5 antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.
Western blot testing of mouse Neuro-2a cell lysate with BIRC5 antibody. Predicted molecular weight ~16 kDa.
Availability 1-2 weeks
Species Reactivity Human, Mouse
Format Purified
Clonality Rabbit Monoclonal
Isotype Rabbit IgG
Clone Name DGD-2
Purity Affinity purified
UniProt O70201
Localization Nuclear, cytoplasmic
Applications Western blot : 1:500-1:2000
Immunohistochemistry (FFPE) : 1:50-1:200
Limitations This Survivin antibody is available for research use only.
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Description

The BIRC5 gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. [RefSeq]

Application Notes

Optimal dilution of the Survivin antibody should be determined by the researcher.

Immunogen

A synthetic peptide specific to human Survivin / Birc5 was used as the immunogen for the Survivin antibody.

Storage

Store the Survivin antibody at -20oC.

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