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Home >> Antibodies >> Survivin Antibody / BIRC5

Survivin Antibody / BIRC5 (N1087)

  Catalog No Formulation Size Price (USD)  
Image N1087-100UG 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 439
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Western blot testing of human samples with Survivin antibody at 2ug/ml. Predicted molecular weight ~16 kDa.
Species Reactivity Human
Format Purified
Host Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Protein A affinity chromatography
Buffer 1X PBS, pH 7.4
Gene ID 332
Applications Western Blot : 2-5ug/ml
Limitations This Survivin antibody is available for research use only.
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Description

Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level.

For a recombinant monoclonal option, see our Survivin Antibody BIRC5/8936R / Apoptosis Inhibitor Survivin Antibody page.

Application Notes

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Immunogen

A recombinant protein fragment from human Survivin was used as the immunogen for this antibody.

Storage

Aliquot the antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Alternate Names

Baculoviral IAP repeat containing 5, BIRC5

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