- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene. It is a member of the IAP (inhibitor of apoptosis family. Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level.
For a recombinant monoclonal option, see our Survivin Antibody BIRC5/8936R / Apoptosis Inhibitor Survivin Antibody page.
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
A recombinant protein fragment from human Survivin was used as the immunogen for this antibody.
Aliquot the antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Baculoviral IAP repeat containing 5, BIRC5
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