- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
STING1 Antibody Clone STING1/7435 / Transmembrane protein 173 [clone STING1/7435] (V5072)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5072-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5072-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5072SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG, kappa |
| Clone Name | STING1/7435 |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This STING1 antibody is available for research use only. |
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Stimulator of interferon genes (STING1) is a transmembrane adaptor protein encoded by the STING1 gene and localized primarily to the endoplasmic reticulum membrane where it plays a central role in innate immune signaling pathways. The STING1 Antibody Clone STING1/7435 recognizes this key immune signaling mediator that is widely studied for its role in host defense mechanisms, antiviral immunity, and inflammatory signaling cascades. STING1 functions as an essential sensor adaptor within the cytosolic DNA detection pathway and is broadly expressed in immune cells including dendritic cells, macrophages, and monocytes, as well as in many epithelial and stromal cell types involved in immune surveillance.
STING1 antibody reagents are commonly used to study the biology of the stimulator of interferon genes protein, also referred to in the literature as MITA (Mediator of IRF3 activation), ERIS (Endoplasmic reticulum interferon stimulator), and TMEM173. Upon detection of cytosolic DNA, cyclic dinucleotides produced by cyclic GMP-AMP synthase (cGAS) bind to STING1 and trigger conformational changes that initiate downstream signaling cascades. Activated STING1 translocates from the endoplasmic reticulum to the Golgi apparatus and recruits TANK-binding kinase 1 (TBK1), leading to phosphorylation of interferon regulatory factor 3 (IRF3). This signaling cascade ultimately promotes transcription of type I interferons and other immune response genes that are essential for antiviral defense and immune regulation.
STING1 is considered a key component of the cGAS-STING signaling pathway, which is one of the primary mechanisms by which cells detect pathogenic DNA in the cytoplasm. Dysregulation of this pathway has been linked to autoimmune diseases, chronic inflammatory disorders, and tumor immune responses. Mutations in the STING1 gene are associated with autoinflammatory syndromes such as STING-associated vasculopathy with onset in infancy (SAVI), highlighting the protein's importance in maintaining balanced immune signaling. In addition to its immune signaling role, STING1 has also been implicated in cancer biology where activation of STING-mediated pathways can influence tumor immune surveillance and anti-tumor immunity.
Because of its central function in innate immune signaling, a STING1 antibody is widely used in studies investigating antiviral defense, DNA sensing pathways, inflammation, and immuno-oncology research. Detection of STING1 expression helps researchers evaluate activation of cytosolic DNA sensing pathways and downstream interferon signaling events. In cellular systems, STING1 localization can shift between the endoplasmic reticulum and perinuclear compartments during activation, reflecting its dynamic role in intracellular signaling complexes. As interest in innate immune activation and cancer immunotherapy continues to expand, STING1 remains an important molecular target for understanding immune signaling networks and therapeutic pathway modulation.
Optimal dilution of the STING1 Antibody Clone STING1/7435 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the STING1 antibody.
Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Stimulator of interferon genes antibody, MITA antibody, ERIS antibody, TMEM173 antibody, STING protein antibody
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