- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
STING1 Antibody Clone STING1/7431 Antibody / TMEM173 [clone STING1/7431] (V9626)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9626-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9626-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V9626SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG |
| Clone Name | STING1/7431 |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This STING1 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Stimulator of interferon genes (STING1) is an endoplasmic reticulum-associated adaptor protein encoded by the STING1 gene that plays a central role in cytosolic DNA sensing and innate immune activation. This signaling protein is a key component of host defense mechanisms that detect pathogenic DNA within the cytoplasm and initiate antiviral immune responses. The STING1 Antibody Clone STING1/7431 recognizes this important immune signaling molecule that is widely studied in inflammation, antiviral immunity, and cancer immunology research. STING1 is expressed in many immune cell populations including dendritic cells, macrophages, monocytes, and lymphoid tissues where innate immune signaling pathways help coordinate early responses to infection.
STING1 antibody reagents are commonly used to investigate the biology of the stimulator of interferon genes protein, also referred to in the literature as STING, MITA (Mediator of IRF3 activation), ERIS (Endoplasmic reticulum interferon stimulator), and TMEM173. Activation of STING1 occurs when cyclic GMP-AMP synthase (cGAS) detects cytosolic double-stranded DNA and generates cyclic GMP-AMP (cGAMP), a cyclic dinucleotide second messenger that binds directly to STING1. This binding event induces conformational changes that trigger STING1 trafficking from the endoplasmic reticulum to Golgi-associated membranes where it forms signaling complexes with downstream kinases.
Following activation, STING1 recruits TANK-binding kinase 1 (TBK1), which phosphorylates interferon regulatory factor 3 (IRF3). Activated IRF3 then translocates to the nucleus to stimulate transcription of type I interferons and interferon-stimulated genes that coordinate antiviral responses. Through this pathway, STING1 acts as a crucial molecular bridge linking detection of intracellular DNA to transcriptional activation of immune response genes. The cGAS-STING pathway is therefore considered one of the most important innate immune surveillance systems in mammalian cells.
Dysregulation of STING signaling has been associated with several human diseases including autoimmune disorders, inflammatory syndromes, and cancer-related immune responses. Gain-of-function mutations in the STING1 gene cause STING-associated vasculopathy with onset in infancy (SAVI), a severe autoinflammatory disease characterized by chronic interferon activation. Conversely, therapeutic activation of STING signaling is being explored as a strategy to stimulate anti-tumor immunity in cancer immunotherapy research. Because of these roles, a STING1 antibody is widely used to examine innate immune signaling pathways, interferon induction, and immune regulation in both normal physiology and disease models.
Optimal dilution of the STING1 Antibody Clone STING1/7431 should be determined by the researcher.
A portion of amino acids 190-290 was used as the immunogen for the STING1 antibody.
Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Stimulator of interferon genes antibody, MITA antibody, ERIS antibody, TMEM173 antibody, STING protein antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
