- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
STING1 Antibody for WB STING1/7437 / STING1 Western Blot Antibody [clone STING1/7437] (V5097)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5097-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5097-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5097SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | STING1/7437 |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This STING1 antibody is available for research use only. |
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Stimulator of interferon genes protein (STING1), encoded by the STING1 gene also known as TMEM173, is an endoplasmic reticulum-associated adaptor protein that plays a central role in innate immune signaling. STING1 Antibody for WB enables detection of this signaling protein by western blot analysis, supporting studies of cytosolic DNA sensing pathways and interferon-mediated immune responses. STING1 functions as a key mediator of the cyclic GMP-AMP synthase (cGAS)-STING signaling pathway, which detects cytosolic DNA derived from pathogens, damaged host cells, or tumor cells. Upon binding cyclic dinucleotides such as cyclic GMP-AMP (cGAMP), STING undergoes conformational activation and translocates from the endoplasmic reticulum to the Golgi apparatus where it recruits downstream signaling molecules including TBK1 and IRF3. Activation of this pathway ultimately leads to transcriptional induction of type I interferons and other inflammatory cytokines that are essential for antiviral defense and innate immune activation.
Western blot analysis is widely used to study STING1 expression and activation states in cultured cells and tissue lysates. The STING1 protein contains multiple transmembrane domains and cytosolic signaling regions that allow interaction with downstream kinase complexes. Following activation of the cGAS-STING pathway, STING1 can undergo post-translational modifications including phosphorylation and ubiquitination that may influence its migration pattern on SDS-PAGE gels. Detection of STING1 by western blot therefore provides valuable insight into expression levels, signaling activation, and immune pathway regulation in experimental systems.
STING1 is broadly expressed in immune and non-immune cell types and contributes to host defense against viral and bacterial infections. Dysregulation of STING signaling has also been implicated in autoinflammatory diseases, cancer immunity, and responses to DNA damage. Because of its central role in innate immune signaling, STING1 antibodies are widely used to investigate cGAS-STING pathway activation and interferon signaling mechanisms.
A mouse monoclonal antibody such as clone STING1/7437 supports detection of STING1 protein in western blot experiments analyzing immune signaling pathways. Reliable detection of STING1 by SDS-PAGE and immunoblotting enables researchers to evaluate expression levels and pathway activation in studies of innate immunity, inflammation, and host defense.
Optimal dilution of the STING1 Antibody for WB STING1/7437 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the STING1 antibody.
Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
STING antibody, TMEM173 antibody, Stimulator of interferon genes protein antibody, Transmembrane protein 173 antibody
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