- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
STING1 Antibody Clone STING1/7439 / ERIS [clone STING1/7439] (V5099)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5099-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5099-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5099SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2c, kappa |
| Clone Name | STING1/7439 |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This STING1 antibody is available for research use only. |
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Stimulator of interferon genes protein (STING1) is an intracellular signaling adaptor encoded by the TMEM173 gene that plays a central role in cytosolic DNA sensing and innate immune activation. STING1 functions as a transmembrane protein primarily localized to the endoplasmic reticulum, where it coordinates signaling events that lead to production of type I interferons and inflammatory cytokines. The STING1 Antibody Clone STING1/7439 recognizes STING1, a critical mediator of the cGAS-STING pathway that links detection of abnormal cytosolic DNA to downstream antiviral immune responses.
STING1 is widely known by several functional names including MITA (Mediator of IRF3 activation), ERIS (endoplasmic reticulum interferon stimulator), and Stimulator of interferon genes protein. These alternate names reflect its central role in innate immune signaling. When cytosolic DNA is detected, cyclic GMP-AMP synthase (cGAS) generates the cyclic dinucleotide cGAMP, which binds directly to STING1 and induces a conformational change that activates the signaling complex. Activated STING then traffics from the endoplasmic reticulum to Golgi-associated vesicles where it recruits the kinase TBK1 and promotes phosphorylation of the transcription factor IRF3. This signaling cascade results in transcription of interferon-stimulated genes and inflammatory mediators that support antiviral defense.
Expression of STING1 occurs across a variety of immune and non-immune cell types including macrophages, dendritic cells, epithelial cells, and endothelial cells. Because STING signaling regulates responses to intracellular pathogens and DNA damage, it has become an important area of investigation in cancer immunology, viral infection, autoimmune disease, and inflammatory signaling pathways. Aberrant activation of the cGAS-STING pathway has been associated with interferon-driven autoinflammatory syndromes, while therapeutic activation of STING is being explored to enhance anti-tumor immune responses.
Mouse monoclonal antibodies such as STING1 Antibody Clone STING1/7439 provide useful tools for investigating STING1 expression and localization in studies of innate immune signaling. Detection of STING1 can assist researchers studying DNA sensing pathways, interferon signaling mechanisms, and the regulation of immune responses triggered by infection, cellular stress, or genomic instability.
Optimal dilution of the STING1 Antibody Clone STING1/7439 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the STING1 antibody.
Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
STING antibody, TMEM173 antibody, MITA antibody, ERIS antibody, Stimulator of interferon genes protein antibody
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