- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
STING1 Antibody Clone STING1/7433 / ERIS / MITA / TMEM17 [clone STING1/7433] (V5093)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5093-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5093-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5093SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG, kappa |
| Clone Name | STING1/7433 |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This STING1 antibody is available for research use only. |
|
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Stimulator of interferon genes protein (STING1) is an intracellular signaling adaptor encoded by the TMEM173 gene that plays a central role in cytosolic DNA sensing and innate immune activation. STING1 is a transmembrane protein primarily localized to the endoplasmic reticulum where it coordinates signaling events that lead to production of type I interferons and inflammatory mediators. The STING1 Antibody Clone STING1/7433 recognizes STING1, a critical component of the cGAS-STING pathway that links detection of abnormal cytosolic DNA to activation of antiviral immune responses.
STING1 is widely known by several alternate names including MITA (Mediator of IRF3 activation), ERIS (endoplasmic reticulum interferon stimulator), and TMEM173. These names reflect the protein's role as a signaling hub that connects cytosolic DNA detection to transcriptional activation of interferon-stimulated genes. In the cGAS-STING pathway, cyclic GMP-AMP synthase (cGAS) detects cytoplasmic DNA and synthesizes the cyclic dinucleotide cGAMP. Binding of cGAMP to STING1 induces conformational activation and promotes trafficking of STING from the endoplasmic reticulum to Golgi-associated vesicles where it recruits the kinase TBK1. TBK1-mediated phosphorylation of the transcription factor IRF3 then drives expression of type I interferons and inflammatory cytokines that initiate antiviral immune responses.
Expression of STING1 occurs in a wide range of immune and non-immune cell types including macrophages, dendritic cells, epithelial cells, endothelial cells, and lymphoid tissues. Through activation of interferon signaling pathways, STING plays an important role in host defense against viral infection and intracellular bacterial pathogens. In addition to pathogen sensing, STING signaling also contributes to immune surveillance mechanisms that detect damaged DNA or genomic instability within cells.
Because of its central role in innate immunity, STING1 has become an important focus in studies of antiviral defense, inflammatory disease, and cancer immunology. Dysregulated activation of the cGAS-STING pathway has been associated with interferon-driven autoinflammatory disorders, while pharmacologic stimulation of STING signaling is being explored as a strategy to enhance anti-tumor immune responses. Mouse monoclonal antibodies such as STING1 Antibody Clone STING1/7433 support investigation of STING1 expression and localization in research examining DNA sensing pathways and interferon-mediated immune signaling.
Optimal dilution of the STING1 Antibody Clone STING1/7433 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the STING1 antibody.
Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
STING antibody, TMEM173 antibody, MITA antibody, ERIS antibody, Stimulator of interferon genes protein antibody
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