- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
STING Antibody Clone STING1/7438 / MITA / ERIS / TMEM17 [clone STING1/7438] (V5098)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5098-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5098-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5098SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | STING1/7438 |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This STING antibody is available for research use only. |
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Stimulator of interferon genes protein (STING1) is an intracellular adaptor protein encoded by the TMEM173 gene that functions as a central regulator of cytosolic DNA sensing and innate immune signaling. STING1 is primarily localized to the endoplasmic reticulum membrane and plays a pivotal role in linking detection of abnormal cytoplasmic DNA to downstream interferon responses. The STING Antibody Clone STING1/7438 recognizes STING1, a signaling protein that activates antiviral immune pathways following detection of foreign or mislocalized DNA within the cytosol.
STING1 is widely known by several alternative names including MITA (Mediator of IRF3 activation), ERIS (endoplasmic reticulum interferon stimulator), and TMEM173. These names reflect the protein's functional role as a signaling hub that connects DNA sensing to transcriptional activation of type I interferon genes. In the cGAS-STING pathway, cyclic GMP-AMP synthase (cGAS) detects cytosolic DNA and produces the cyclic dinucleotide cGAMP. Binding of cGAMP to STING1 induces conformational activation and promotes translocation of STING from the endoplasmic reticulum to Golgi-associated compartments where it recruits the kinase TBK1. This interaction leads to phosphorylation and activation of the transcription factor IRF3, ultimately stimulating expression of interferon-stimulated genes and inflammatory mediators.
STING signaling is essential for host defense against viral infection and intracellular bacteria. Expression of STING1 is observed in multiple immune and non-immune cell types including macrophages, dendritic cells, epithelial cells, endothelial cells, and lymphoid cells. Activation of the cGAS-STING pathway triggers antiviral responses and supports innate immune surveillance mechanisms that detect microbial pathogens and damaged cellular DNA.
Beyond infectious disease, STING signaling has emerged as an important pathway in cancer biology and inflammatory disorders. Aberrant activation of STING can contribute to interferon-driven autoinflammatory syndromes, while pharmacologic activation of the STING pathway is actively being explored as a strategy to enhance anti-tumor immunity. Antibodies such as STING Antibody Clone STING1/7438 provide useful tools for investigating STING expression and localization in studies of innate immune signaling, interferon responses, and DNA damage-associated immune activation pathways.
Optimal dilution of the STING Antibody Clone STING1/7438 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the STING antibody.
Aliquot the STING antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
STING1 antibody, TMEM173 antibody, MITA antibody, ERIS antibody, Stimulator of interferon genes protein antibody
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